When it gains entry into the lungs, they get phagocytosed by the alveolar macrophages. They then disseminate into the Central nervous system where it causes meningoencephalitis. The yeast-like fungus gains entry into the human host via inhalation of aerosolized basidiospores. The fungus has the ability to colonize phagocytic cells and undergoes vomocytosis, hence it escapes phagocytosis without processing. Cryptococcus neoformans is a facultative intracellular pathogen, which uses human phagocytes to spread within the body. Cryptococcus neoformans affect immunocompetent persons but more often in patients with HIV/AIDS, tuberculosis, hematogenous malignancies, and hospitalized patients majorly those with invasive devices. This infection is otherwise known as cryptococcosis, which is a systemic infection primarily involving the lungs and central nervous system. The yeast then migrates to the central nervous system causing meningoencephalitis. 
Its human pathogenicity is via inhalation of desiccated yeast cells or small basidiospores. 
Cryptococcus neorformans distinguishes from other fungal yeasts by the presence of a polysaccharide capsule, the formation of melanin, and urease activity, which all function as virulence determinants.laurentii and C.gittii are mildly pathogenic. albidus and C.laurentii are the most common species and C.neorformans is the most pathogenic of these species, for both humans and animals, while C. There are four known species of Cryptococcus:.
They undergo sexual reproduction forming dikaryotic hyphae and basidiospores supported by a club-shaped basidium with hyphae that has a complex septate.Cryptococcus spp is a fungal group that belongs to the Phylum Basidiomycota (Basidiomycetes).
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